Setting the Scene
- Traditional drug discovery methods are slow, expensive, and have high failure rates. - The average drug discovery takes 10-15 years. 
- The economic burden exceeds more than $655B annually. 
- The failure rate of drugs for neurodegenerative diseases is about 99%. 
 
- This week’s company leverages AI to identify targets of neurological diseases and generate drug candidates. 

In a Sentence
NeuroX1 utilizes AI to identify drivers of neurological diseases to improve the drug discovery process. 
- Drivers: The platform analyzes biological data to uncover underlying causes behind brain diseases. 
- Discovery: NeuroX1 designs computational compounds, potentially speeding up the time consuming process of drug discovery. 
Bulleted Version: Similar to how Waze analyzes traffic for route optimization, NeuroX1 analyzes biochemical data to find the quickest route to drug discovery.

The Basics
- Industry: Biotech 
- Headquarters: Austin, TX 
- Year founded: 2021 
- Employee count: 10 
- Investors: Drive Capital, Trousdale Partners, Vibe Capital, Syntax Ventures, Next Sequence VC, Techstars 
- Amount raised: $2.12 million 
- Currently raising: $2 million Seed extension 
- Business model: B2B; Upfront payment for early discovery and then progressively increasing milestones as drug assets progress through each phase of clinical development, plus a royalty if approved. 
- Early traction: 3 industry co-development partnerships and 2 academic collaborations. 

IN PARTNERSHIP WITH
- Crafting your startup’s cash management strategy? 
- First, divide your funds into three categories: liquid, short-term, and strategic. 
- From there, it’s about optimizing for risk and yield according to those time horizons. 
- But how much should you put in each category? 

Due Diligence
WHAT WE LIKE
- Market Opportunity: The neurological disorder drugs market is expected to grow nearly 5% annually due to the rising prevalence of diseases among aging populations and demand for treatments. 
- Drug Discovery: NeuroX1's use of generative chemistry dramatically shortens the time and reduces the cost needed to find new drugs, representing a major leap forward in medicine development. 
- Innovative Business Model: The company’s B2B model, which combines upfront payments with milestones and royalties, aligns incentives across the drug development process while fostering innovation. 
POTENTIAL RISKS
- AI Hallucinations: Like other advanced algorithms, NeuroX1’s platform might generate chemically valid but biologically unproven structures, potentially leading to redirected research paths and careful client expectation management. 
- Non-Recurring Revenue: While NeuroX1 has an innovative monetization model, its dependence on performance could delay unrealized annualized revenue. 
- Algorithm Overlap: If NeuroX1's AI learns and adapts from multiple lab projects simultaneously, there's a risk that one project's discovery process could inadvertently influence another's, diluting the exclusive value of expensive, proprietary research for organizations. - / 

Founder Profile
- Max Dordevic, CEO: Former CEO of Veritas Innovation and life science researcher. 
- Lucas Myers, CTO: Software engineer with a background in applied math, healthcare data pipelines, infrastructure, and product management. 
- Conner Myers, PhD, CIO: Physicist and high-performance computing expert, specialized in GPU acceleration of physics simulations at Lawrence Livermore and Sandia National Labs. 
To request an introduction to the founder, respond to this email.

Comps
- Cradle: Backed by Kindred Capital, Index Ventures, and others. 
- CHARM Therapeutics: Backed by NVentures, General Catalyst, Khosla Ventures, F-Prime Capital, and others. 
- Aquemia: Backed by Wendel Growth, Bpifrance, Eurazeo, and others. 
- Pangea Botanica: Backed by No Label Ventures, Seaside Ventures, Kadmos Kapital, and others. 
Why NeuroX1: By slashing costs, speeding up development, and boosting the success rate of finding new treatments for brain disorders, NeuroX1 could be the necessary cure for the pharmaceutical industry.
Event Board
- Thanks to all of you who came out to our event last night. More to come… 

Cast Your Vote
What do you think of NeuroX1?
Last Week Today
- The results are in: Blockpliance, a platform that arms institutions against illicit blockchain transactions, was favored in last week’s poll. 
- Subscriber feedback: “Blockpliance gives the power back to financial institutions to ensure the security of virtual transactions — It’s a no-brainer.” 
✍️ Written by Brett



